Specifications
| Sequence | Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg |
| Amino Acids | 16 |
| Molecular Formula | C101H152N28O22S2 |
| Molecular Weight | 2174.64 g/mol |
| CAS Number | 1627580-64-6 |
| Gene Origin | Mitochondrial 12S rRNA gene region |
| Form | Lyophilized powder |
| Quantity | 40mg per vial |
An indirect route to AMPK
MOTS-C does not hit AMPK directly the way pharmaceutical activators do. Instead, it inhibits the folate cycle, which causes AICAR (5-aminoimidazole-4-carboxamide ribonucleotide) to accumulate. AICAR is an endogenous AMPK activator. So MOTS-C activates the central energy sensor of the cell, but through an upstream metabolic bottleneck rather than direct kinase binding. Under stress conditions, the peptide translocates from mitochondria to the nucleus to regulate gene expression — a retrograde signal where the organelle talks back to the genome.
MOTS-C vs NAD+
Both sit at the intersection of energy metabolism and cellular signaling, but through different nodes. NAD+ fuels sirtuins, PARPs, and the electron transport chain. MOTS-C activates AMPK through the folate cycle. Complementary pathways, not redundant ones. Heritage Labs USA carries both.
Research applications
- AMPK pathway activation and downstream signaling
- Folate-methionine cycle and AICAR accumulation
- Mitochondrial-nuclear retrograde signaling
- Glucose uptake and fatty acid oxidation studies
- Cellular stress response and metabolic adaptation
Frequently paired with
- MOTS-C 10mg — Same peptide, 10mg per vial.
- BPC-157 5mg — Complementary recovery pathways.
- NAD+ 500mg — AMPK + sirtuin axis research.
Storage
- Lyophilized: -20°C
- Reconstituted: 2-8°C, use within 30 days
For laboratory research use only. Not for human or veterinary use. Not a drug, food, or cosmetic.
Technical reference adapted from the original Heritage Labs USA product listing. This description is not a certificate of analysis or evidence of testing for inventory supplied by this store.
