Specifications
| Amino Acids | 37 |
| Parent Protein | hCAP-18 |
| Molecular Formula | C205H340N60O53 |
| Molecular Weight | 4493.33 g/mol |
| CAS Number | 154947-66-7 |
| Structure | Amphipathic alpha-helix |
| Form | Lyophilized powder |
| Quantity | 5mg per vial |
Mechanism of action
The amphipathic alpha-helical structure is the key. One face of the helix is hydrophobic, the other hydrophilic. This lets LL-37 interact with the negatively charged phospholipids in bacterial membranes, leading to permeabilization. MIC studies have characterized activity against panels of gram-positive and gram-negative organisms. But the antimicrobial activity is only part of the story.
Beyond killing bacteria
Published research documents LL-37 as a chemotactic agent that recruits neutrophils, monocytes, and T cells through FPRL1 receptor interactions. It modulates TLR4 inflammatory signaling. It participates in VEGF-mediated angiogenesis and EGFR transactivation in epithelial models. And at sub-MIC concentrations, it disrupts bacterial biofilms by interfering with matrix components and quorum sensing.
Frequently paired with
- BPC-157 5mg — Immune and tissue recovery research.
Storage
- Lyophilized: -20°C
- Reconstituted: 2-8°C, use within 30 days
For laboratory research use only. Not for human or veterinary use.
Technical reference adapted from the original Heritage Labs USA product listing. This description is not a certificate of analysis or evidence of testing for inventory supplied by this store.
