GHK-CU 50mg

A molecule that programs genes

The Broad Institute’s Connectivity Map database revealed something striking: GHK-Cu affects the expression of roughly 4,048 human genes, approximately 6% of the genome. The pattern is consistent — upregulation of collagen, growth factors, integrins, elastin, decorin, and glycosaminoglycans, alongside downregulation of inflammatory mediators and excess metalloproteinases (Pickart & Margolina, Int J Mol Sci, 2018; PMC6073405).

Plasma levels tell their own story: roughly 200 ng/mL at age 20, dropping to about 80 ng/mL by age 60. The copper(II) ion is not just structural scaffolding — it is functionally active in roughly 30 copper-dependent enzyme systems.

Specifications

Research areas

Extracellular matrix remodeling

Pickart’s original work in rat wound models established the foundation — GHK-Cu influences collagen synthesis, decorin production, and glycosaminoglycan expression in fibroblast cultures (Nature, 1980; PubMed 7453802).

MMP regulation

Research has examined GHK-Cu’s effects on MMP-2, MMP-9, and TIMP balance — the metalloproteinase system that governs ECM turnover and remodeling.

Antioxidant interactions

Flow cytometry and ESR spin-trapping studies have characterized interactions with SOD activity, glutathione peroxidase pathways, and hydroxyl/peroxyl radical species.

Anti-inflammatory pathways

Preclinical work in cigarette smoke-induced lung inflammation models documented NF-κB pathway modulation and Nrf2 activation effects on inflammatory mediator expression (Pickart & Margolina, 2018).

GHK-Cu vs BPC-157

Different compounds, different mechanisms. GHK-Cu works through copper-dependent enzymatic pathways and gene expression modulation. BPC-157 works through connective tissue models and nitric oxide signaling. Heritage Labs USA carries both individually and together in the Glow 50/10/10 blend (GHK-Cu + BPC-157 + TB-500).

Research applications

• Peptide-metal complex characterization via LC-MS
• Fibroblast and keratinocyte cell culture studies
• ECM remodeling and collagen expression analysis
• Copper-dependent enzyme pathway research
• Gene expression profiling and Connectivity Map analysis
• Antioxidant and anti-inflammatory pathway screening

Storage

• Lyophilized: -20°C for long-term stability
• Reconstituted: 2-8°C, use within 30 days
• Protection: Shield from light and moisture

Frequently paired with

• BPC-157 5mg — Also available in Glow 50/10/10.
• Epithalon 10mg — Telomerase-focused research.
• SNAP-8 10mg — SNARE complex studies.

References

1. Pickart L, et al. “Growth-modulating plasma tripeptide may function by facilitating copper uptake into cells.” Nature. 1980;288(5792):715-717. PubMed 7453802
2. Pickart L, Margolina A. “Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data.” Int J Mol Sci. 2018;19(7):1987. PMC6073405
3. Park JR, et al. “The tri-peptide GHK-Cu complex ameliorates lipopolysaccharide-induced acute lung injury in mice.” Oncotarget. 2016;7(36):58405-58417.

For laboratory research use only. Not for human or veterinary use. Not a drug, food, or cosmetic.

Technical reference adapted from the original Heritage Labs USA product listing. This description is not a certificate of analysis or evidence of testing for inventory supplied by this store.